Publications


G. Gonzalez-Parra, H.M. Dobrovolny, (2017) `Modeling of fusion inhibitor treatment of RSV', submitted to Journal of Theoretical Biology.

L. Pinky, G. Gonzalez-Parra, H.M. Dobrovolny, (2017) `Superinfection and cell regeneration can lead to chronic viral coinfections', submitted to Scientific Reports.

L.A.C. Deecke, H.M. Dobrovolny, (2017) `Intermittent treatment of influenza', submitted to Journal of Theoretical Biology.

G. Gonzalez-Parra, F. De Ridder, D. Huntjens, D. Roymans, G. Ispas, H.M. Dobrovolny (2017) `A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time', submitted to PLOS One.

B. Tuladhar, H.M. Dobrovolny (2017), `A Comparative Modeling Study of the Dose Dependent Effects of Antiarrhythmics on a Cardiac Cell', submitted to Plos One.

G. Gonzalez-Parra, H.M. Dobrovolny, D.F. Aranda, B.M. Chen-Charpentier, R. Guerrero (2017) `Quantifying rotavirus kinetics in the REH tumor cell line', accepted in Virus Research.

H.M. Dobrovolny, C.A.A. Beauchemin (2017) `Modelling the Emergence of Influenza Drug Resistance: The Roles of Surface Proteins, the Immune Response and Antiviral Mechanisms', Plos One 12(7): e0180582.. [Article]

L. Pinky, H.M. Dobrovolny (2017) `The impact of cell regeneration on the dynamics of viral coinfection', Chaos 27:063109. [Article]

J. Palmer, H.M. Dobrovolny, C.A.A. Beauchemin (2017), 'The in vivo efficacy of neuraminidase inhibitors cannot be determined from the decay of influenza viral titers observed in treated patients.' Sci. Rep. 7:40210. [Article]

L.Pinky, H.M. Dobrovolny (2016), `Coinfections of the respiratory tract: Viral competition for resources', PLOS One 11(5):e0155589. [Article]

G. Gonzalez-Parra, T. Rodriguez, H.M. Dobrovolny (2016), `A comparison of methods for extracting influenza viral titer characteristics', J. Virol. Meth, 231:14-24.

H. Murphy, H. Jaafari, H.M. Dobrovolny (2016), 'Differences in predictions of ODE models of tumor growth: A cautionary example', BMC Cancer, 16(1):163.[Article]

G. Gonzalez-Parra, H.M. Dobrovolny (2015) `Assessing uncertainty in A2 respiratory syncytial virus (RSV) viral dynamics', Comput. Math. Meth. Medicine 2015:567589.[Article]

N.F. Beggs, H.M. Dobrovolny (2014), `Determining drug efficacy parameters for mathematical models of influenza.' J. Biol. Dyn. 9(S1):332-46.[Article]

H.M. Dobrovolny, M.B. Reddy, M.A. Kamal, C.R. Rayner, C.A.A. Beauchemin (2013), ‘Assessing mathematical models of influenza infections using features of the immune response.’ PLoS One 8(2):e57088. [Article]

H.M. Dobrovolny, R. Gieschke, B.E. Davies, N.L. Jumbe, C.A.A. Beauchemin (2011) ‘Neuraminidase inhibitors for treatment of human and avian strain influenza: A comparative modeling study.’ J. Theor. Biol. 269:234-244. [Article]

H.M. Dobrovolny, M.J. Baron, R. Gieschke, B.E. Davies, N.L. Jumbe, and C.A.A. Beauchemin (2010) ‘Exploring cell tropism as a possible contributor to influenza infection severity.’ PLoS One, 5(11):e13811. [Article]

H.M. Dobrovolny, C.M. Berger, N.H. Brown, W. Krassowska Neu, D.J. Gauthier (2009) ‘Spatial Heterogeneity of Restitution Properties and the Onset of Alternans.’ Proceedings of 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Sep. 6:4186-4189.[Article]

D.W. Evertson (In Memoriam), M.R. Holcomb, M.D.C. Eames, M.-A.P. Bray, V.Y. Sidorov, J. Xu, H. Wingard, H.M. Dobrovolny, M.C. Woods, D.J. Gauthier, and J.P. Wikswo (2008) ‘High-resolution high-speed panoramic cardiac imaging system.’ IEEE Trans. Biomed. Eng. 55:1241-1243. [Article]

C.M. Berger, X. Zhao, D.G. Schaeffer, W. Krassowska, H.M. Dobrovolny, D.J. Gauthier (2007) ‘Period-doubling bifurcation to alternans in paced cardiac tissue: Crossover from smooth to border-collision characteristics.’ Phys. Rev. Lett. 99:058101. [Article]

N.H. Brown, H.M. Dobrovolny, P.D. Wolf, D.J. Gauthier (2007) ‘A Fiber-Based Ratiometric Optical Cardiac Mapping Channel using a Diffraction Grating and Split Detector.’ Biophys J. 93:254-263. [Article]

S.S. Kalb, H.M. Dobrovolny, E. Tolkacheva, S.F. Idriss, W. Krassowska, D.J. Gauthier (2004) ‘The restitution portrait: A new method for investigating rate-dependent restitution.’ J. Cardiovasc. Electrophys. 15:698-709. [Article]

C.J. Cellucci, P.D. Brodfuehrer, R. Acera-Pozzi, H.M. Dobrovolny, E. Engler, J. Los, R. Thompson, A.M. Albano (2000) ‘Linear and nonlinear measures predict swimming in the leech.’ Phys. Rev. E 62:4826-4834. [Article]


Presentations


H.M. Dobrovolny, `Modeling of tumor growth and treatment with oncolytic viruses.' Workshop on Biological & Medical Science Based on Physics: Radiation and physics, Physics in medical science, Modeling for biological systems, Kyoto, Japan, November 5-7, 2015

D. Barth, C. Huey-You, H. Jaafari, H. Murphy, M. Ellis, H.M. Dobrovolny, `Searching for an optimal ODE model to describe and differentiate cancers.' Fall 2015 Joint meeting of the Texas Section of the AAPT, Texas section of the APS and Zone 13 of SPS, Waco, TX, Oct. 29-31, 2015.

C. Huey-You, D. Barth, H. Jaafari, H. Murphy, M. Ellis, H.M. Dobrovolny, `Tumor growth model choice in the presence of limited data.' Fall 2015 Joint meeting of the Texas Section of the AAPT, Texas section of the APS and Zone 13 of SPS, Waco, TX, Oct. 29-31, 2015.

B. Tuladhar, H.M. Dobrovlny, `Studying the effect of antiarrhythmic drugs on rate-dependent behavior of human cardiac cells.' Fall 2015 Joint meeting of the Texas Section of the AAPT, Texas section of the APS and Zone 13 of SPS, Waco, TX, Oct. 29-31, 2015.

T. Rodriguez, H.M. Dorbovolny, `Basic reproduction number for in-host viral infections.' Fall 2015 Joint meeting of the Texas Section of the AAPT, Texas section of the APS and Zone 13 of SPS, Waco, TX, Oct. 29-31, 2015.

G. Gonzalez-Parra, F. De Ridder, A. Vermeulen, G. Ispas, H.M. Dobrovolny, `Comparison of in vitro influenza and RSV kinetics parameters.' 2nd Workshop on Virus Dynamics, Toronto, ON, July 17-18, 2015.

B. Tuladhar, H.M. Dobrovolny, `The effect of antiarrhythmic drugs on rate-dependent cardiac behavior.' Society for Mathematical Biology, Atlanta, GA, June 2015.

L. Deecke, H.M. Dobrovolny, `Preventing drug resistance in severe influenza.' APS March meeting, San Antonio, TX, March 1-6, 2015.

B. Tuladhar, H.M. Dobrovolny, `The effect of antiarrhythmic drugs on rate-dependent cardiac behavior.' APS March meeting, San Antonio, TX, March 1-6, 2015.

L. Pinky, H.M. Dobrovolny, `Impact of cell regeneration in human respiratory tract on simultaneous viral infections.' APS March meeting, San Antonio, TX, March 1-6, 2015.

L. Pinky, H.M. Dobrovolny, `Simultaneous influenza and respiratory syncytial virus infections in human respiratory tract.' APS March meeting, San Antonio, TX, March 1-6, 2015.

T. Rodriguez, H.M. Dobrovolny, `Determining mechanism of action of antivirals for respiratory illnesses.' APS March meeting, San Antonio, TX, March 1-6, 2015.

T. Rodriguez, H.M. Dobrovolny, `Basic reproduction number of a gamma-distributed within-host infection model.' APS March meeting, San Antonio, TX, March 1-6, 2015.

H. Murphy, H. Jaafari, H.M. Dobrovolny, `How bad is it doc? The varying predictions of ODE cancer growth models.' 59th annual meeting of the Biophysical Society, Baltimore, MD., Feb. 21-24, 2015

L. Deecke, H.M. Dobrovolny, `Minimizing the emergence of drug resistance mutants with periodic treatment of severe influenza.' Dynamics Days, Houston, TX, January 5-7, 2015.

B. Tuladhar, H.M. Dobrovolny, `Comparing the effect of antiarrhythmic agents on rate-dependent behavior of cardiac cells.' Dynamics Days, Houston, TX, January 5-7, 2015.

L. Pinky, H.M. Dobrovolny, `Investigating Simultaneous RSV And Influenza Infection Of The Upper Respiratory Tract.' 9th Respiratory Syncytial Virus Symposium, Stellenbosch, South Africa, November 9-13, 2014.

L. Pinky, H.M. Dobrovolny, `Investigation of Dual Virus Infection of Human Respiratory Tract.' Society of Industrial and Applied Mathematics Conference on the Life Sciences, Charlotte, NC, August 4-7, 2014.

B. Tuladhar, H.M. Dobrovolny, `Modeling the Effect of Antiarrhythmic Agents on the Action Potential of Human Ventricular Cells.' Society of Industrial and Applied Mathematics Conference on the Life Sciences, Charlotte, NC, August 4-7, 2014.

I.T. Rodriguez, H.M. Dobrovolny, ` Determining Mechanism of Action and Efficacy of Novel Influenza Antivirals.' Society of Industrial and Applied Mathematics Conference on the Life Sciences, Charlotte, NC, August 4-7, 2014.

H. Jafaari, H. Murphy, M. Ellis, H.M. Dobrovolny, ` Determining An Optimal Mathematical Model for Tumor Growth.' Society of Industrial and Applied Mathematics Conference on the Life Sciences, Charlotte, NC, August 4-7, 2014.

M. Ellis, H.M. Dobrovolny, `Modelling spread of oncolytic viruses in heterogeneous cell populations.' American Physical Society March meeting, Denver, CO, March 3-7, 2014.

H. Jaafari, M. Ellis, H.M. Dobrovolny, `Assessing ODE models of tumor growth.' American Physical Society March meeting, Denver, CO, March 3-7, 2014.

H.M. Dobrovolny, M.B. Reddy, M.A. Kamal, C.R. Rayner, C.A.A. Beauchemin, ‘Assessing mathematical models of influenza infections using features of the immune response.’ Oral presentation at 1st Workshop on Viral Dynamics, Frankfurt, Germany, July 15-16, 2013.

H.M. Dobrovolny, M.B. Reddy, M.A. Kamal, C.R. Rayner, C.A.A. Beauchemin, ‘What do we really know about the role of the immune response in influenza?’, Poster presentation at XV International Symposium on Respiratory Viral Infections, Rotterdam, Netherlands, March 14-18, 2013.

H.M. Dobrovolny, K.D. Poore, C.A.A. Beauchemin, 'Evaluating the efficacy of drug treatment of infectious diseases using mathematical models', Poster presentation at Gordon Conference on Tropical Infectious Diseases, Galveston, TX, February 10-15, 2013.

H.M. Dobrovolny, K.D. Poore, C.A.A. Beauchemin, ‘Evaluating the efficacy of drug treatment of influenza’, Oral presentation at the Workshop for Young Researchers in Mathematical Biology, Columbus, OH, August 27-30, 2012.

H.M. Dobrovolny, K.D. Poore, C.A.A. Beauchemin, ‘Characterizing monotherapy and combination therapy of influenza’, Oral presentation at SMB, Knoxville, TN, July 25-28, 2012.

K.D. Poore, H.M. Dobrovolny, C.A.A. Beauchemin, ‘Toward a better evaluation of optimal antiviral combination therapy in treating influenza infection’, Poster presentation at SHARCNET Research Day, Guelph, ON, May 23, 2012 (Winner of best poster award).

H.M. Dobrovolny, K.D. Poore, C.A.A. Beauchemin, ‘Characterizing influenza drug treatments’, Oral presentation at SHARCNET Research Day, Guelph, ON, May 23, 2012.

H.M. Dobrovolny, The role of mathematical modelling in understanding influenza infections, IDEAS Seminar, Fields Institute, Toronto, ON, January 20, 2012

H.M. Dobrovolny, What can mathematical modelling tell us about influenza? Mathematical Biology Research Seminar, McMaster University, Hamilton, ON, October 13, 2011.

H.M. Dobrovolny, The effect of external packaging on the dynamics of drug-resistant influenza virus, AMMCS, Waterloo, ON, July 26, 2011.

M. Shahbaba, H.M. Dobrovolny, C.A.A. Beauchemin, ‘Characterizing the efficacy of combination antiviral therapy for the treatment of influenza’, Poster presentation at AMMCS, Waterloo, ON, July 25-29, 2011.

N. Younis, B.P. Holder, H.M. Dobrovolny, C.A.A. Beauchemin, ‘Investigating the impactof cell tropism on influenza infection spread in computer-simulated lung tissue’, Poster presentation at AMMCS, Waterloo, ON, July 25-29, 2011.

J. Palmer, H.M. Dobrovolny, C.A.A. Beauchemin, ‘Modelling time-dependent drug concentrations with constant drug concentration in within host models of influenza’, Poster presentation at AMMCS, Waterloo, ON, July 25-29, 2011.

H.M. Dobrovolny, C.A.A. Beauchemin, ‘Investigating the immune response in within host models of influenza’, Oral presentation at ICIAM, Vancouver, BC, July 18-July 23, 2011.

H.M. Dobrovolny, ‘Modelling the emergence of influenza drug resistance using stochastic ordinary differential equations’, Oral presentation at Sharcnet Research Day, Oakville, ON, May 19, 2011.

B.P. Holder, H.M. Dobrovolny, W. Wong, T. Ngo, P. Simon, G. Boivin, C.A.A. Beauchemin, ‘How mathematical and computer models can enhance classic virological assays’, Poster presentation at XIII International Symposium on Respiratory Viral Infections, Rome, Italy, March 13–16, 2011.

H.M. Dobrovolny, Modelling of influenza infections, Keynote Speaker Graduate Research Conference, York University, Toronto, ON, October 14, 2010.

H.M. Dobrovolny, Neuraminidase inhibitor treatment of seasonal and severe influenza, Thematic Program on Mathematics of Infectious Diseases, Fields Institute, Toronto, ON, July 13, 2010

H.M. Dobrovolny, G. Boivin, A.S. Perelson, C.A.A. Beauchemin, ‘Modeling the emergence of influenza drug resistance under various drug therapies’, Oral presentation at CAP, Toronto, ON, June 6-June 12, 2010.

H.M. Dobrovolny, R. Gieschke, B. Davies, N.L. Jumbe, C.A.A. Beauchemin, ‘Why late treatment with neuraminidase inhibitors is effective in treating more severe influenza infections.’ Poster presentation at the Pandemic H1N1 Influenza Meeting, Atlanta, GA, April 17-22, 2010.

H.M. Dobrovolny, R. Gieschke, B. Davies, N.L. Jumbe, C.A.A. Beauchemin, ‘Why late treatment with neuraminidase inhibitors is effective in treating more severe influenza infections.’ Poster presentation at the XIIth International Symposium on Respiratory Viral Infections, Taipei (Taiwan), March 1114, 2010.

H.M. Dobrovlny, Introduction to Membrane Biophysics, Physics Colloquium, York University, Toronto, ON, September 22, 2009.

H.M. Dobrovolny, `Spatial Heterogeneity of Restitution Properties and the Onset of Alternans', 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September 4, 2009

H.M. Dobrovolny, `Modeling the emergence of influenza drug resistance under various drug therapies', Infectious Diseases Seminar, York University, Toronto, ON, July 6, 2009

H.M. Dobrovolny, C.A.A. Beauchemin, G. Boivin, A.S. Perelson, ‘Modeling the emergence of influenza drug resistance under various drug therapies’, Poster presentation at MITACS, Fredericton, NB, May 31-June 5, 2009.

D.J. Gauthier, C.M. Berger, X. Zhao, H.M. Dobrovolny, D.G. Schaeffer, W. Krassowska, ‘Evidence for an unfolded border-collision bifurcation in paced cardiac muscle,’ Oral presentation at Nonlinear Dynamics Seminar, U. Maryland, College Park, MD, Apr. 17, 2008.

H.M. Dobrovolny, `Stability of Cardiac Rhythms', York University, Toronto, ON, May 25, 2007.

C.M. Berger, X. Zhao, D.G. Schaeffer, H.M. Dobrovolny, W. Krassowska, D.J. Gauthier, ‘Evidence for an unfolded border-collision bifurcation in paced cardiac tissue,’ Poster presentation at Dynamics Days 2007, Boston, MA, Jan. 2-6, 2007

D.J. Gauthier, C.M. Berger, X. Zhao, D.G. Schaeffer, H.M. Dobrovolny, W. Krassowska, ‘Discovery of a new type of bifurcation in paced cardiac muscle,’ Oral presentation at Third Wrokshop Promotionskolleg, Helmholtz Center for Brain and Mind Dynamics, Liebenwalde, Germany, July 14, 2006.

C.M. Berger, H.M. Dobrovolny, X. Zhao, D.G. Schaeffer, W. Krassowska, D.J. Gauthier, ‘Investigating a Period-Doubling Bifurcation in Cardiac Tissue Using Alternate Pacing,’ Poster presentation at Dynamics Days 2006, Bethesda, MD, Jan. 4-7, 2006.

C.M. Berger, H.M. Dobrovolny, D.G. Schaeffer, W. Krassowska, D.J. Gauthier, ‘Evidence for a border-collision bifurcation in paced cardiac tissue,’ Oral presentation at Southeastern Section of the APS, Gainesville, FL, November 10-12, 2005.

H.M. Dobrovolny, C.M. Berger, S. Kalb, S. Idriss, D. Schaeffer, W. Krassowska, D.J. Gauthier, ‘Spatial heterogeneity of the restitution portrait correlates with alternans in paced cardiac tissue,’ Poster presentation at Heart Rhythm, New Orleans, LA, May 4-7, 2005. [Heart Rhythm, 2:S297 (2005)]

C.M. Berger, H.M. Dobrovolny, S.S. Kalb, S.F. Idriss, D.G. Schaeffer, D.J. Gauthier, W. Krassowska, ‘Investigating a Period-Doubling Bifurcation in Cardiac Tissue using Alternate Pacing,’ Oral presentation at American Physical Society, Los Angeles, CA, March 21-25, 2005.

H.M. Dobrovolny, E.G. Tolkacheva, D.J. Gauthier, ‘Spatiotemporal dynamics and control of alternans in cardiac tissue with short-term memory,’ Oral presentation at APS March meeting, Los Angeles, CA, Mar. 21-25, 2005.

H.M. Dobrovolny, `Action potential and Conduction Velocity Restitution in Cardiac Tissue', Nonlinear Dynamics Seminar Series, Duke University, Durham, NC, November 4, 2004.

H.M. Dobrovolny, R. Oliver, S. Kalb, E.G. Tolkacheva, W. Krassowska, and D.J. Gauthier, ‘Conduction velocity dispersion in cardiac tissue,’ Oral presentation at 2004 CAP Congress, Winnipeg, Canada, June 13-16, 2004.

H.M. Dobrovolny, R. Oliver, S. Kalb, E.G. Tolkacheva, D.G. Schaeffer, W. Krassowska, D.J. Gauthier, ‘Action Potential and Conduction Velocity Restitution in Cardiac Tissue’, Oral presentation at APS March Meeting, Montreal, Canada, March 21-26, 2004.

H.M. Dobrovolny, `Bioelectricity: Techniques for Measuring Electrical Activity in Living Tissue', Graduate Seminar Series, Duke University, Durham, NC, February 2004.

H.M. Dobrovolny, `Recent Developments in Cardiac Dynamics', University of Cambridge, Cambridge, UK, November 26, 2003.

H.M. Dobrovolny, `Cardiac Dynamics: The New Restitution Portrait', Graduate Seminar Series, Duke University, Durham, NC, November 2003.

H.M. Dobrovolny, S. Sau, H. Elmariah, D.J. Gauthier, J. Gilligan, J. Wikswo, ‘Use of LEDs for imaging cardiac tissue,’ Poster presentation at Gordon Research Conference on Cardiac Arrhythmia Mechanisms, New London, NH, August 10-15, 2003.

S. Sau, H.M. Dobrovolny, E.G. Tolkacheva, D.G. Schaeffer, W. Krassowska, D.J. Gauthier, ‘New Experimental Protocol for Simultaneous Measurement of the S1S2, Constant-BCL and Dynamic Restitution Curves,’ Poster presentation at Gordon Research Conference on Cardiac Arrhythmia Mechanisms, New London, NH, August 10-15, 2003 (Winner of Best Experimental Poster Award).

H.M. Dobrovolny, S. Sau, H. Elmariah, D.J. Gauthier, J. Gilligan, J. Wikswo, ‘Use of LEDs for imaging cardiac tissue,’ Poster presentation at 2nd annual Fitzpatrick Center Conference, Durham, NC, May 27-28, 2003.

H.M. Dobrovolny, S. Sau, E.G. Tolkacheva, D.G. Schaeffer, W. Krassowska, D.J. Gauthier, ‘New Experimental Protocol for Simultaneous Measurement of the S1S2, Constant-BCL and Dynamic Restitution Curves,’ Poster presentation at NASPE, Washington, DC, May 14-17, 2003.

H.M. Dobrovolny, S. Sau, E.G. Tolkacheva, D.G. Schaeffer, W. Krassowska, D.J. Gauthier, ‘Stability of cardiac response patterns’, Poster presentation at Dynamics Days, January, 2003.