Publications

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  Impact of Indole Inclusion in the Design of Multi-Tactical Metal-Binding Tetra-Aza Macrocycles that Target the Molecular Features of Neurodegeneration

  Kristof Pota, Shrikant Nilewar, Christina Mantsorov, Lindsay Zumwalt, Nam Nguyen, Cam-eron J. Bowers, David M. Freire, Robert B. Benafield III, Giridhar R. Akkaraju, Kayla N. Green

  ACS Chemical Neuroscience 2024, ASAP.

  

  Hydrogen Peroxide Disproportionation Activity Is Sensitive to Pyridine Substitutions on Manganese Catalysts Derived from 12-Membered Tetra-Aza Macrocyclic Ligands

  David M. Freire, Hannah M. Johnston, Katherine J. Smith, Kristof Pota, Magy A. Mekhail, Sugam Kharel, and Kayla N. Green

  Inorganic Chemistry. 2023, 62(39), 15842-15855.

  

  Increased Efficiency of a Functional SOD Mimic Achieved with Pyridine Modification on a Pyclen-Based Copper(II) Complex

  Magy A. Mekhail, Katie J. Smith, David M. Freire, Kristof Pota, Nhan Nguyen, Marianne E. Burnett, Kayla N. Green

  Inorganic Chemistry. 2023, 62 (14), 5415-5425.

  

  A Model for the Rapid Assessment of Solution Structures for 24-Atom Macrocycles: The Impact of β-Branched Amino Acids on Conformation

  Menke, A. J.; Gloor, C. J.; Claton, L. E.; Mekhail, M. A.; Pan, H.; Stewart, M. D.; Green, K. N.; Reibenspies, J. H.; Pavan, G. M.; Capelli, R.; Simanek, E. E.

  The Journal of Organic Chemistry 2023, 88 (5), 2692-2702.d

  

  Synthesis and Characterization of Two Piperazine Containing Macrocycles and their Transition Metal Complexes

  Kristof Pota, Hannah M. Johnston, E. Madarasi, Gyula Tircsó,  Kayla N. Green

  Journal of Inorganic Biochemistry, 2023, 112124

  

  Pyridine modifications regulate the electronics and reactivity of Fe–pyridinophane complexes

  Magy A. Mekhail, Kristof Pota, Sugam Kharel, David M. Freire, Kayla N. Green

  Dalton Transactions, 2023, 52, 892-901

  

  A macrocyclic molecule with multiple antioxidative activities protects the lens from oxidative damage

  Jinmin Zhang, Yu Yu, Magy A. Mekhail, Hongli Wu, and Kayla N. Green

  Frontiers in Chemistry, 2022, 10: 996604

  

  Manganese (III/IV) μ-Oxo Dimers and Manganese (III) Monomers with Tetraaza Macrocyclic Ligands and Historically Relevant Open-Chain Ligands

  Hannah M. Johnston, David M. Freire, Christina Mantsorov, Nena Jamison, Kayla N. Green

  European Journal of Inorganic Chemistry, 2022, ASAP

  

  pH Dependent Concatenation of an Inorganic Complex Results in Solid State Helix Formation

  Emily Hoffer, Brian P. Niebuhr, Kristof Pota, Timothy M. Schwartz, Marianne E. Burnett, Timothy J. Prior, Horst Puschmann, Kayla N. Green

  Inorg. Chim. Acta 2021, 120740

  

  Mechanistic Insights into Iron-Catalyzed CH Bond Activation and C-C Coupling

  Samantha M. Brewer, Timothy M. Schwartz, Magy A. Mekhail, Lara S. Turan, Timothy J. Prior, Timothy J. Hubin, Benjamin G. Janesko, and Kayla N. Green

  Organometallics 2021, 40 (15), 2467-2477.

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  Functionalized pyridine in pyclen-based iron (III) complexes: evaluation of fundamental properties

  Mekhail, M. A.; Pota, K.; Schwartz, T. M.; Green, K. N.

  RSC Advances 2020, 10 (52), 31165-31170.

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  Manganese Complex of a Rigidified 15-Membered Macrocycle: A Comprehensive Study

  Pota, K.; Molnár, E.; Kálmán, F. K.; Freire, D. M.; Tircsó, G.; Green, K. N.

  Inorg. Chem. 2020, 59 (16), 11366-11376.

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  Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups

  Yepremyan, A.; Mekhail, M. A.; Niebuhr, B. P.; Pota, K.; Sadagopan, N.; Schwartz, T. M.; Green, K. N.

  The Journal of Organic Chemistry 2020, 85 (7), 4988-4998.

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  Hydrogen peroxide disproportionation with manganese macrocyclic complexes of cyclen and pyclen

  Freire, D. M.; Beeri, D.; Pota, K.; Johnston, H. M.; Palacios, P.; Pierce, B. S.; Sherman, B. D.; Green, K. N.

  Inorg. Chem. Front. 2020, 7, 1573-1582.

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  Electronic influence of substitution on the pyridine ring within NNN pincer-type molecules

  Schwartz, T. M.; Burnett, M. E.; Green, K. N.

  Dalton Trans. 2020, 49, 2356-2363.

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  Enhancement of antioxidant activity and neurotherapeutic features through pyridol addition to tetra-azamacrocyclic molecules

  Johnston, H. M.; Pota, K.; Barnett, M. M.; Kinsinger, O.; Braden, P.; Schwartz, T. M.; Hoffer, E.; Sadagopan, N.; Nguyen, N.; Yu, Y.; Gonzalez, P.; Tircsó, G.; Wu, H.; Akkaraju, G.; Chumley, M. J.; Green, K. N.

  Inorganic Chemistry 2019, 58(24), 16771-16784.

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  Dialing in on pharmacological features for a therapeutic antioxidant small molecule.

  Green, K. N.; Pota, K.; Tircso, G.; Davda, C.; Hyde, K.; Gonzalez, P.; Brewer, S.; Johnston, H. M.; Akkaraju, G.

  Dalton Trans. 2019, 48, 12430-12439.

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  Environmental effects of chitosan as an immobilization medium electrochemically active small molecules.

  Burnett, M. E.; Bodiford, N.; Coffer, J. L.; Green, K. N.

  Journal of Coordination Chemistry 2019, 72(13), 2160-2176

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  Nitrogen-doped graphene quantum dots: Optical properties modification and photovoltaic applications

  Hasan, Md.T.; Gonzalez-Rodriguez, R.; Ryan, C.; Pota, K.; Green, K. N.; Coffer, J. L.; Naumov, A.N.

  Nano Research, 2019, 12(5), 1041–1047

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  Increase of Direct C–C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes

  Brewer, S. M.; Wilson, K. R.; Jones, D. G.; Reinheimer, E. W.; Archibald, S. J.; Prior, T. J.; Ayala, M. A.; Foster, A. L.; Hubin, T. J.; Green, K. N.

  Inorganic Chemistry 2018, 57(15), 8890-8902

• Crystallographic Characterization and Non‐Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on Eu(III) Electrochemistry

  Burnett, M. E., Adepesin, B.; Ratnakar, S. J.; Green K.N.

  Eur J Inorg Chem 2018, (14), 1556-1562

• Isolation and Identification of the Pre-Catalyst in Iron-Catalyzed Direct Arylation of Pyrrole with Phenylboronic Acid

  Brewer, S. M.; Palacios, P. M.; Johnston, H. M.; Pierce, B. S.; Green, K. N.

  Inorg Chim Acta 2018, 478, 139-147

• A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

  Yepremyan, A.; Mehmood, A.; Brewer, S. M.; Barnett, M. M.; Janesko, B. G.; Akkaraju, G.; Simanek, E. E.; Green, K. N.

  RSC Advances 2018, 8 (6), 3024-3035

• Electrochemical Investigation of the Eu3+/2+ Redox Couple in Complexes with Variable Numbers of Glycinamide and Acetate Pendant Arms

  Burnett, M. E.; Adebesin, B.; Funk, A. M.; Kovacs, Z.; Sherry, A. D.; Ekanger, L. A.; Allen, M. J.; Green, K. N.; Ratnakar, S. J.

  Eur J Inorg Chem 2017, (43), 5001-5005

• Synthesis, characterization, and activity of a triazine bridged antioxidant and antiamyloidogenic small molecule

  Gonzalez, P., Akkaraju, G.; da Costa V. C. P., Green, K. N.

  Acs Chem Neurosci. 2017, 8 (11), 2414-2423

• Hybrid antioxidant and metal sequestering small molecules targeting the molecular features of Alzheimer’s disease

  Green, K. N., Johnston, H. M.; Burnett, M.E., Brewer, S

  Comments on Inorganic Chemistry 2017, 37(3) 146-167

• Spectroscopic and solid state evaluations of tetra-aza macrocyclic cobalt complexes with parallels to the classic cobalt(II) chloride equilibrium

  Johnston, H. M., Palacios, P. M., Pierce, B., Green, K. N.

  Journal of Coordination Chemistry 2016, 69, 1979-1989. Invited article for special issue, Emerging Leaders in Coordination Chemistry.

• Triosmium carbonyl complexes with multiple PTA ligands: synthesis of a new water-soluble Os3 cluster

  Dugan, J., Nolan, B.S., Brehm, K.L., Jackson, J.L., Gwini, N. Floris, S.D., Marolf, D.M., Johnstone, J.E., Yoon, S.H., Powell, G.H., Nesterov, V.N., Johnston, H.M., Green, K.N.

  Polyhedron 2016, 114, 292-298

• Structural characterization of the aquaporin inhibitor 2-nicotinamido-1,3,4-thiadiazole

  Burnett, M.E., Johnston, H.M., Green, K.N.

  Acta Cryst 2015, C71, 1074–1079

• Chemical Characteristics of the Products of the Complexation Reaction Between Copper(II) and a Tetra-aza Macrocycle in the Presence of Chloride Ions

  Lincoln, K. M.; Johnston, H. M.; Green, K. N.

  Journal of Coordination Chemistry, 2015, 68, 2810-2826

• Altered Nrf2 Signaling Mediates Hypoglycemia-induced Blood–Brain-Barrier Endothelial Dysfunction in-vitro

  Sajja, R. K.; Green, K. N.; Cucullo, L.

  PLoS ONE 2015, 10 (3), e0122358

• Development of Low Molecular Weight Ferrocene-Biotin Bioconjugates as Electrochemical Sensors. Organometallics

  Scarborough, J. H. Brusoski, K.; Brewer, S. M.; Rodich, S.; Chatley, K. S.; Nguyen, T.; Green, K. N.

  Organometallics, 2015, 34(5), 918-925

• Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

  Scarborough, J. H.; Gonzalez, P.; Rodich, S.; Green, K. N.

  J. Vis. Exp. 2015, 97, e52399

• Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer’s disease

  Gonzalez, P.; da Costa, V. C. P.; Hyde, K.; Wu, Q.; Annunziata, O.; Rizo, J.; Akkaraju, G.; Green, K. N.

  Metallomics 2014, 6, 2072-2082

• Structural, Spectral, and Electrochemical Properties of Nickel(11), Copper(II), and Zinc(II) Complexes Containing 12-Membered Pyridine- and Pyridol-Based Tetra-aza Macrocycles

  Lincoln, K. M.; Offutt, M. E.; Hayden, T. D.; Saunders, R. E.; Green, K. N.

  Inorg. Chem. 2014, 53 (3), 1406-1416

• Ligand effects on the redox behavior of bimetallic tungsten(0)/ferrocene(II) complexes

  Moore, A.; Shufelt, K.; Janesko, B. G.; Green, K. N.

  Polyhedron 2014, 72, 50-55

• A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

  Lincoln, K. M.; Gonzalez, P.; Richardson, T. E.; Julovich, D. A.; Saunders, R.; Simpkins, J. W.; Green, K. N.

  Chem. Commun. 2013, 49, 2712-2714

• An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation

  Lincoln, K. M.; Richardson, T. E.; Rutter, L.; Gonzalez, P.; Simpkins, J. W.; Green, K. N.

  ACS Chem. Neurosci. 2012, 3 (11), 919-27

• Neuroprotective actions of methylene blue and its derivatives

  Poteet, E.; Winters, A.; Yan, L. J.; Shufelt, K.; Green, K. N.; Simpkins, J. W.; Wen, Y.; Yang, S. H.

  PLoS One 2012, 7 (10), e48279

• Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors

  Ratnakar, S. J.; Viswanathan, S.; Kovacs, Z.; Jindal, A. K.; Green, K. N.; Sherry, A. D.

  J. Am. Chem. Soc. 2012, 134 (13), 5798-800

• Europium(III) DOTA-Derivatives Having Ketone Donor Pendant Arms Display Dramatically Slower Water Exchange

  Green, K. N.; Viswanathan, S.; Rojas-Quijano, F. A.; Kovacs, Z.; Sherry, A. D.

  Inorg. Chem. 2011, 50 (5), 1648-1655

• T2 exchange agents: A new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation

  Soesbe, T. C.; Merritt, M. E.; Green, K. N.; Rojas-Quijano, F. A.; Sherry, A. D

  Magn. Reson. Med. 2011, 66 (6), 1697-1703

• Alternatives to Gadolinium-Based Metal Chelates for Magnetic Resonance Imaging

  Viswanathan, S.; Kovacs, Z.; Green, K. N.; Ratnakar, S. J.; Sherry, A. D

  Chem. Rev. 2010, 110 (5), 2960-3018

• Multi-frequency PARACEST agents based on europium(III)-DOTA-tetraamide ligands

  Viswanathan, S.; Ratnakar, S. J.; Green, K. N.; Kovacs, Z.; De Leon-Rodriguez, L. M.; Sherry, A. D..

  Angew. Chem. 2009, 48 (49), 9330-3

• Resin-bound models of the [FeFe]-hydrogenase enzyme active site and studies of their reactivity

  Green, K. N.; Hess, J. L.; Thomas, C. M.; Darensbourg, M. Y.

  Dalton Trans. 2009, (22), 4344-4350.

• Chemical Issues Addressing the Construction of the Distal Ni[Cysteine-Glycine-Cysteine]2- Site of Acetyl CoA Synthase: Why Not Copper?

  Green, K. N.; Brothers, S. M.; Lee, B.; Darensbourg, M. Y.; Rockcliffe, D. A.

  Inorg. Chem. 2009, 48 (7), 2780-2792

• Electronic Effects of (N2S2)M(NO) Complexes (M = Fe, Co) as Metallodithiolate Ligands

  Hess, J. L.; Conder, H. L.; Green, K. N.; Darensbourg, M. Y.

  Inorg. Chem. 2008, 47 (6), 2056-2063

• S K-Edge XAS and DFT Calculations on Square-Planar NiII-Thiolate Complexes: Effects of Active and Passive H-Bonding

  Dey, A.; Green, K. N.; Jenkins, R. M.; Jeffrey, S. P.; Darensbourg, M.; Hodgson, K. O.; Hedman, B.; Solomon, E. I.

  Inorg. Chem. 2007, 46 (23), 9655-9660

• An Experimental and Computational Study of Sulfur-Modified Nucleophilicity in a Dianionic NiN2S2 Complex

  Green, K. N.; Brothers, S. M.; Jenkins, R. M.; Carson, C. E.; Grapperhaus, C. A.; Darensbourg, M. Y.

  Inorg. Chem. 2007, 46 (18), 7536-7544

• The acetyl CoA synthase paradigm for hybrid bio-organometallics: Quantitative measures for resin-bound Ni-Rh complexes

  Green, K. N.; James, W. D.; Cantillo, A. V.; Darensbourg, M. Y.

  J. Organomet. Chem.. 2007, 692 (6), 1392-1397

• NiN2S2 complexes as metallodithiolate ligands to Rh-I, Rh-II and Rh-III

  Jeffery, S. P.; Green, K. N.; Rampersad, M. V.; Reibenspies, J. H.; Darensbourg, M. Y.

  Dalton Trans. 2006, (35), 4244-4252

• A nickel tripeptide as a metallodithiolate ligand anchor for resin-bound organometallics

  Green, K. N.; Jeffery, S. P.; Reibenspies, J. H.; Darensbourg, M. Y.

  J. Am. Chem. Soc. 2006, 128 (19), 6493-6498